TOXICITY OF BISPHENOL A ON THE GROWTH OF ZEBRAFISH EMBRYOS

College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China

Funds:

National Natural Science fund(30340091, 30470319)

Abstract: In order to evaluate the toxicity of the bisphenol A (BPA)on the growth of zebrafish embryos, fertilized eggswere exposed to the concentration of 2. 00, 4. 00, 6. 00, 8. 00, 10. 00, 15. 00, 18. 00, 22. 00 and 25. 00mg/ L BPA for 72 h at 26 1℃. The resultsrevealed that the sublethal toxicological endpoints induced by BPA were: delayed hatchblood balk cystaltered axial curvature and tail malformation. The median embryo lethal concentration(LC50)after 24 hwas16. 36mg/L. We concluded that the BPA toxicity on zebrafish embryoswere caused before 8h exposure and it was not the result of long -term accumulation. Therefore, BPA maybe cause altered gene expression at the early stage of zebrafish embryos. In the further studies, we will use the technology of genetic chips to look for the toxic mechanism of BPA.
- Bisphenol A

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