Abstract: In the process of intensive aquaculture farmed fish commonly suffer from excessive lipid accumulation, which often leads to metabolic disorders, inflammation, and reduction of disease resistance. The above problems seriously impede the sustainability of aquaculture. As lipid sensors, peroxisome proliferator-activated receptors (PPARs) play an important role in the process of lipid metabolism. PPARs includes three isoforms: PPARα, PPARβ/δ and PPARγ. Notably, PPARγ is considered to be an extremely critical regulator of lipid metabolism, and also plays an important role in the cell differentiation, energy metabolic homeostasis and inflammation. This paper briefly reviewed the regulatory roles of Pparγ on the lipid and fatty acid metabolism, lipid droplet homeostasis, adipocyte differentiation, and its influencing factors, which provide a reference for systematically elucidating the mechanisms of Pparγ on the lipid metabolism in fish, and lay the foundation for promoting the green development of aquaculture.