Abstract: Drug resistance is the capacity of disease-causing pathogens to withstand drugs previously toxic to them, which is acquired by spontaneous mutation or through selective pressure after drug exposure. With the intensification of aquaculture and the extensive use of available compounds, parasite drug resistance has become more and more serious and widespread, which not only affects the efficacy of antiparasitic agents, but also brings about environmental pollution and food safety problems. This paper reviews the drugs for treating parasitic diseases of terrestrial animals, the mechanisms of drug resistance, the detecting assays of drug resistance, the treatment strategies to slow down the development of drug resistance, and the current status of parasite drug resistance in farming aquatic animals. This review aims to provide research framework for understanding parasite drug resistance and to propose effective treatment strategies for parasitic diseases in aquaculture in China.