Abstract: To explore the effects of periodical starvation-refeeding on growth performance, antioxidant indices, digestive enzyme activities of Paramisgurnus dabryanus, the P. dabryanus were divided into 4 groups, including starvation 2d and refeeding 4d (S2F4 group), starvation 2d and refeeding 6d (S2F6 group), starvation 2d and refeeding 8d (S2F8 group) and continuous feeding (control group) for a 30-days trial. The results showed that (1) the body length and specific growth rate were similar among groups (P>0.05), and the body weight and weight gain ratio of S2F8 were significantly higher than those of the control group (P<0.05). (2) The condition factor, visceral index and hepatosomatic index showed no differences among groups. (3) At 15d, the activity of SOD in S2F8 and CAT in S2F6 and S2F8 increased significantly compared with those of the control group (P<0.05), the activity of GSH-PX in S2F6 and S2F8 was higher than that of the control group (P<0.05). At 30d, the activity of SOD in S2F6 and S2F8 and CAT in S2F6 were higher than those of the control group (P<0.05), the activity of GSH-PX in S2F6 and S2F8 was higher than that of the control group (P<0.05). (4) The activity of protease, amylase and lipase showed no difference between each time (P>0.05). At 30d, the activities of lipase in S2F6 and S2F8 were lower than those of the control group (P<0.05). These results indicated compensatory growth in the periodical starvation-refeeding groups with the increase of antioxidant enzyme activity and the decrease of digestive enzyme activity, suggesting that the feeding mode of S2F8 can be used in P. dabryanus culture.