Abstract: With the rapid development of Internet and large-scale, intensive, industrialized, refined and information-based aquaculture industry, the aquaculture industry will gradually enter an era of intelligent transformation and upgrading. The realization of aquaculture management information and intelligence can significantly reduce the cost and improve the economic and ecological benefits of aquaculture. Based on the data of bioenergy and culture production, we established a precise feeding management model under the condition of intensive culture of Lates calcarifer and built a precise feeding management assistant system through the development of software, which can predict the growth, feed requirement of Lates calcarifer at any time point and pollution of nitrogen and phosphorus discharged from water during the breeding period. The results showed that there was a allometric growth point in the growth cycle of Lates calcarifer that divided into two growth stages: <296 g (stage 1) and >296 g (stage 2). Compared with other growth models (SGR, ADG, DGC), the revised thermal-unit growth coefficient (TGC) model can more accurately predict the growth of Lates calcarifer in two growth stages. The digestible energy requirement of the Lates calcarifer was about 2.33×10⁷ kJ per ton (body weight was 1—1000 g). The total solid waste output from the consumption of 1t feed or the production of 1t fish was 349 kg and 543 kg based on Lates calcarifer which were fed with 44.4% and 42.6% crude protein in stage 1 and stage 2, respectively. There was a significant correlation between the predicted and observed values of body weight of Lates calcarifer, but the observed values of FCR was significantly higher than that of the predicted values, which may explained by the excessive use of feed. These results indicate that the precision fish farming model can effectively estimate the growth and feed requirement of Lates calcarifer in precision culture operation. The developed precision feeding management assistant system has laid a theoretical and technical foundation for the precision and informatization of fish feeding management.