Abstract: In this study, we used Oryzias melastigma as the experimental animal and used Cuprum and cadmium as the test drugs. The effects on the feeding behavior of Oryzias melastigma exposed to Cu²⁺ and Cd²⁺ were analyzed, including the response time of feeding behavior, food intake, the success rate of feeding and feeding efficiency. The results showed that with an increase in the Cuprum concentration, the food intake initially increased to the maximum food intake, associated with the shortest feeding response time, and then decreased at a concentration of 0.174 mg/L. A low concentration of Cu²⁺ improved the feeding success rate and feeding efficiency of Oryzias melastigma, while a high concentration of Cu²⁺ and long-term exposure resulted in the opposite effects. Cd²⁺ had a significant inhibitory effect on the feeding behavior of Oryzias melastigma, and the lowest observed effect concentration of Cd²⁺ that inhibited the feeding of Oryzias melastigma was 0.65 mg/L. Moreover, the food intake, feeding success rate and feeding efficiency decreased with an increasing Cd²⁺ concentration. The response time to food was significantly shorter for females than for males, and that of the group was significantly shorter than those of individuals.