Abstract: An 8-week growth experiment was conducted to investigate the effect of dietary replacement of fish meal protein with meat and bone meal (MBM) on growth performance, feed utilization, blood physiological and biochemical indices, muscle chemical composition and texture characteristics in juvenile Furong crucian carp (Furong carp♀× red crucian carp♂) initial body weight of (17.47±2.56) g. Three isonitrogenous (crude protein: 38%) and isolipidic (Crude lipid: 6.5%) diets were formulated with 0, 50% and 100% dietary fish meal protein replaced by MBM (designated FM, T1 and T2). The results showed that, no significant differences were found in weight gain rate (WGR), specific growth rate (SGR) and feeding rate (FR) among the FM, T1 and T2 groups (P>0.05), while the feed conversion ratio (FCR) of the FM group was significantly higher than that of the T2 group (P<0.05). There was no significant difference in blood physiological and serum biochemical indices, except for the hemoglobin (HGB) and aspartic amino transferase (AST). The HGB content in the T1 and T2 groups, was significantly higher than that in the FM group (P<0.05). On the other hand, AST showed a downward trend with the increasing proportion of dietary MBM, and the AST of the T2 group was significantly higher than that of the FM group. The crude lipid content of the dorsal muscle in the T1 group was significantly lower than that in the FM group. Meanwhile, with the replacement of dietary fish meal with MBM, the Asp, Glu, Gly, Ala, Val, Met, Ile, Leu, Tyr, Phe, ΣEAA, ΣDAA and ΣTAA contents of dorsal muscle were decreased, while the elasticity and adhesion of dorsal muscle were increased. In summary, MBM is an acceptable alternative animal protein source for Furong crucian carp, and 100% dietary fish meal could be replaced by MBM without significantly adverse effects on the growth of Furong crucian carp.