Langenau D M, Feng H, Berghmans S, et al. Cre/lox- regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia [J]. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102(17): 60686073

Xiong F, Wei Z Q, Zhu Z Y, et al. Targeted Expression in Zebrafish Primordial Germ Cells by Cre/loxP and Gal4/UAS Systems [J]. Marine Biotechnology (NY), 2013, 15(5): 526539

Reid L H, Shesely E G, Kim H S, et al. Cotransformation and gene targeting in mouse embryonic stem cells [J]. Molecular Cell Biology, 1991, 11(5): 27692777

Capecchi M R. Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century [J]. Nature Reviews Genetics, 2005, 6(6): 507512

Glaser S, Anastassiadis K, Stewart A F. Current issues in mouse genome engineering [J]. Nature Genetics, 2005, 37(11): 11871193

Jasin M. Genetic manipulation of genomes with rare-cutting endonucleases [J]. Trends in Genetics, 1996, 12(6): 224228

Porteus M. Using homologous recombination to manipulate the genome of human somatic cells [J]. Biotechnology Genetic Engineering Reviews, 2007, 24: 195212

Beumer K J, Trautman J K, Bozas A, et al. Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases [J]. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(50): 1982119826

Meyer M, De Angelis M H, Wurst W, et al. Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases [J]. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107(34): 1502215026

Cui X, Ji D, Fisher D A, et al. Targeted integration in rat and mouse embryos with zinc-finger nucleases [J]. Nature Biotechnology, 2011, 29(1): 6467

Zu Y, Tong X, Wang Z, et al. TALEN-mediated precise genome modification by homologous recombination in zebrafish [J]. Nature Methods, 2013, 10(4): 329360

Sonoda E, Hochegger H, Saberi A, et al. Differential usage of non-homologous end-joining and homologous recombination in double strand break repair [J]. DNA Repair (Amst), 2006, 5(910): 10211029

Liang F, Han M, Romanienko P J, et al. Homology-directed repair is a major double-strand break repair pathway in mammalian cells [J]. Proceedings of the National Academy of Sciences of the United States of America, 1998, 95(9): 51725177

Liu J, Gong L, Chang C, et al. Development of novel visual-plus quantitative analysis systems for studying DNA double-strand break repairs in zebrafish [J]. Journal of Genetics and Genomics, 2012, 39(9): 489502

Hiom K. Coping with DNA double strand breaks [J]. DNA Repair (Amst), 2010, 9(12): 12561263

O'driscoll M, Jeggo P A. The role of double-strand break repair - insights from human genetics [J]. Nature Reviews Genetics, 2006, 7(1): 4554

Ninomiya Y, Suzuki K, Ishii C, et al. Highly efficient gene replacements in Neurospora strains deficient for nonhomologous end-joining [J]. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101(33): 1224812253

Verbeke J, Beopoulos A, Nicaud J M. Efficient homologous recombination with short length flanking fragments in Ku70 deficient Yarrowia lipolytica strains [J]. Biotechnology Letters, 2012, 35(4): 571576

Kretzschmar A, Otto C, Holz M, et al. Increased homologous integration frequency in Yarrowia lipolytica strains defective in non-homologous end-joining [J]. Current Genetics, 2013, 59(12): 6372

Abdel-Banat B M, Nonklang S, Hoshida H, et al. Random and targeted gene integrations through the control of non-homologous end joining in the yeast Kluyveromyces marxianus [J]. Yeast, 2010, 27(1): 2939

Barnes D E, Stamp G, Rosewell I, et al. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice [J]. Current Biology, 1998, 8(25): 13951398

Guirouilh-Barbat J, Huck S, Bertrand P, et al. Impact of the KU80 Pathway on NHEJ-Induced Genome Rearrangements in Mammalian Cells [J]. Molecular Cell, 2004, 14(5): 611623

Nishizawa-Yokoi A, Nonaka S, Saika H, et al. Suppression of Ku70/80 or Lig4 leads to decreased stable transformation and enhanced homologous recombination in rice [J]. New Phytologist, 2012, 196(4): 10481059

Pellegrini L, Yu D S, Lo T, et al. Insights into DNA recombination from the structure of a RAD51-BRCA2 complex [J]. Nature, 2002, 420(6913): 287293

Kim P M, Allen C, Wagener B M, et al. Overexpression of human RAD51 and RAD52 reduces double-strand break- induced homologous recombination in mammalian cells [J]. Nucleic Acids Research, 2001, 29(21): 43524360

Vispe S, Cazaux C, Lesca C, et al. Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation [J]. Nucleic Acids Research, 1998, 26(12): 28592864

Lieschke G J, Currie P D. Animal models of human disease: zebrafish swim into view [J]. Nature Reviews Genetics, 2007, 8(5): 353367

Yang M Y, Wang H P, Zhu Z Y, et al. Cloning, identification and expression analysis of Ca15b, a novel gene specifically expressed in primordial germ cells of zebrafish [J]. Acta Hydrobiologia Sinica, 2014, 38(1): 142149 [杨明宇, 王厚鹏, 朱作言, 等. 斑马鱼ca15b的克隆及在原始生殖细胞中的特异表达. 水生生物学报, 2014, 38(1): 142149]

Li G H, Cui Z B, Zhu Z Y, et al. Introduction of foreign gene carried by sperms [J]. Acta Hydrobiologia Sinica, 1996, 20(3): 242247 [李国华, 崔宗斌, 朱作言, 等. 鱼类精子携带的外源基因导入. 水生生物学报, 1996, 20(3): 242247]

Kimmel C B, Ballard W W, Kimmel S R, et al. Stages of embryonic development of the zebrafish [J]. Developmental Dynamics, 1995, 203(3): 253310

Westerfield M. The Zebrafish Book: a Guide for the Laboratory Use of Zebrafish (Danio rerio) [M]. Inst of Neuro Science, 1995, 128

Bontems F, Stein A, Marlow F, et al. Bucky ball organizes germ plasm assembly in zebrafish [J]. Current Biology, 2009, 19(5): 414422

Amsterdam A, Lin S, Hopkins N. The Aequorea victoria green fluorescent protein can be used as a reporter in live zebrafish embryos [J]. Developmental Biology, 1995, 171(1): 123129

Wu P Y, Frit P, Meesala S, et al. Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4 [J]. Molecular And Cellular Biology, 2009, 29(11): 31633172

He F, Li L, Kim D, et al. Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions [J]. Cancer Research, 2007, 67(2): 634642

Blaser H, Eisenbeiss S, Neumann M, et al. Transition from non-motile behaviour to directed migration during early PGC development in zebrafish [J]. Journal of Cell Science, 2005, 118(Pt 17): 40274038

Fan L, Moon J, Wong T T, et al. Zebrafish primordial germ cell cultures derived from vasa: RFP transgenic embryos [J]. Stem Cells and Development, 2008, 17(3): 585597

Knaut H, Steinbeisser H, Schwarz H, et al. An evolutionary conserved region in the vasa 3'UTR targets RNA translation to the germ cells in the zebrafish [J]. Current Biology, 2002, 12(6): 454466

Krovel A V, Olsen L C. Expression of a vas: EGFP transgene in primordial germ cells of the zebrafish [J]. Mechanisms of Development, 2002, 116(1-2): 141150

Barnes D E, Stamp G, Rosewell I, et al. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice [J]. Current Biology, 1998, 8(25): 13951398

Kuhfittig-Kulle S, Feldmann E, Odersky A, et al. The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV [J]. Mutagenesis, 2007, 22(3): 217233

Ochiai H, Sakamoto N, Fujita K, et al. Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos [J]. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(27): 1091510920

Paffett K S, Clikeman J A, Palmer S, et al. Overexpression of Rad51 inhibits double-strand break-induced homologous recombination but does not affect gene conversion tract lengths [J]. DNA Repair (Amst), 2005, 4(6): 687698

Schild D, Wiese C. Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability [J]. Nucleic Acids Research, 2010, 38(4): 10611070